• Ipriflavone
Isoflavones are plant-based compounds that resemble estrogen at the molecular level. In the bone tissue, isoflavones act as balanced, estrogen-like hormones which activate osteoblast cells, promoting new bone formation. Isoflavones also increase cell-signaling proteins that may inhibit the bone-absorbing activity of osteoclast cells.
• Calcium
Nearly all calcium within the adult skeletal system exists as a complex paired with phosphorus, called hydroxyapatite. In 1990, the USDA published a trial comparing the inexpensive calcium carbonate with calcium citrate-malate, with respect to improved bone density, in post-menopausal women. In this trial, researchers found the citrate-malate form was significantly more effective in supporting bone health than the carbonate form. OsteoPrev is formulated with calcium citrate-malate, as well as calcium hydroxyapatite, to improve calcium absorption and utilization for healthy bone density.
• Magnesium
Magnesium plays a major role in bone formation as approximately 50% of magnesium found in the body is found in the bone. Magnesium plays numerous roles in bone health including increasing calcium absorption, acting as a cofactor for alkaline phosphatase activation, and supporting vitamin D3 conversion in the body.
• Vitamin D3 (Cholecalciferol)
Vitamin D is a steroid vitamin known for its role in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract. Emerging research shows a direct correlation between bone mineral density and serum levels of 25(OH)D3, the active form of vitamin D.
• Vitamin K1 (Phytonedione) and Vitamin K2 (Menaquinone)
Vitamin K is responsible for synthesizing osteocalcin, a protein involved in calcium transport and properly embedding calcium into bone tissue. Vitamin K has also been shown to decrease the activity of osteoclasts, helping to maintain bone formation and strength. Vitamin K works synergistically with vitamin D3 to improve calcium absorption and helps to bind newly absorbed calcium to the bone matrix.
• Boron
Improving boron levels has been shown to support skeletal strength.
• Phosphorus
Phosphorus plays a role in bone mineralization and is a component of hydroxyapatite crystals in bone.