Effective radioprotective actions show that including melatonin as an adjuvant in radiation therapy may decrease the normal tissue damage induced by irradiation, which leads to more tumor control by use of higher doses of irradiation during radiotherapy.

Furthermore, due to its antitumor and radiosensitizing properties, treatment with melatonin is likely to increase damage to the tumor.

• Direct anti-neoplastic effects.
• Decreases cell proliferation at low concentrations.
• Direct cytotoxic effect occurs with high concentrations
• Stimulation of cell differentiation
• Induction of apoptosis
• Anti-angiogenesis
• A synergistic effect has been found in several cancer types when it is administered in combination with chemotherapy.
• Melatonin activates anti-neoplastic immune reactivity
• Direct anticancer action
• Protects against chemo radiation damage

Some studies of interest showing benefits of high doses of melatonin:

Govender, Jenelle, Ben Loos, and Anna-Mart Engelbrecht. “Melatonin: a protective role against doxorubicin-induced cardiotoxicity.” Future Oncology 11.14 (2015): 2003-2006.

Mills, Edward, et al. “Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta nalysis.” Journal of pineal research 39.4 (2005): 360-366.

Lissoni, P., et al. “Increased survival time in brain glioblastomas by a radio neuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone.” Oncology 53.1 (1996): 43-46.

Thomas, Charles R., Russel J. Reiter, and Terence S. Herman. “Melatonin: from basic research to cancer treatment clinics.” Journal of Clinical Oncology 20.10 (2002): 2575-2601.

Srinivasan, Venkataramanujan, et al. “Therapeutic actions of melatonin in cancer: possible mechanisms.” Integrative Cancer Therapies 7.3 (2008): 189-203.

Blask, David E., Leonard A. Sauer, and Robert T. Dauchy. “Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy.” Current topics in medicinal chemistry 2.2 (2002): 113-132.

Conti, Ario, and Georges JM Maestroni. “The clinical neuroimmunotherapeutic role of melatonin in oncology.” Journal of pineal research 19.3 (1995): 103-110.

Alonso-González, Carolina, et al. “Melatonin sensitizes human breast cancer cells to ionizing radiation by down-regulating proteins involved in double-strand DNA break repair.” Journal of pineal research 58.2 (2015): 189-197.

Alonso-González, Carolina, et al. “Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis.” Cancer letters 370.1 (2016): 145-152.

Loh, D., & Reiter, R. J. (2023). Light, water, and melatonin: The synergistic regulation of phase separation in dementia. International Journal of Molecular Sciences, 24(6), 5835\ https://doi.org/10.3390/ijms24065835

Tavakoli, Maryam. “Kidney protective effects of melatonin.” Journal of Nephropharmacology 3.1 (2015).

At The James Clinic, we prioritize product quality, offering both our own supplements and selections from trusted manufacturers that meet our stringent standards for safety and effectiveness.

Much like prescription medications, supplements are powerful tools requiring careful consideration. Our expertise lies in recommending top-tier supplements tailored to specific health needs, such as gut health, nutrient deficiencies, or blood sugar regulation.

We select supplements with easily absorbed forms of essential nutrients, often yielding better results than conventional therapies alone.

All products in our store are "professional grade," undergoing thorough third-party testing for quality and purity. These supplements come from reputable US-based manufacturers, adhere to NSF or USP certifications, and are manufactured in FDA cGMP-compliant facilities, ensuring FDA standards are met.